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KMID : 0363220120500110982
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Korean Journal of Dermatology
2012 Volume.50 No. 11 p.982 ~ p.986
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Pityriasis Rubra Pilaris Treated with Infliximab
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Choi Joon-Seok
Kim Ji-Hoon
Yun Jeong-Hwan
Kang Hong-Kyu
Baek Jin-Ok
Lee Jong-Rok
Roh Joo-Young
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Abstract
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Pityriasis rubra pilaris (PRP) is a chronic papulosquamous disorder of unknown etiology, which may pose therapeutic challenges. There is currently no universally effective treatment for PRP, and some cases are resistant to multiple topical and systemic therapies. Systemic retinoids, methotrexate, several immunosuppressive agents and phototherapy have all been used with varying degrees of success. Recently, a few reports have appeared in the literature, concerning the use of biologics in combination therapies and/or in refractory PRP cases. We report a case of PRP similar to type II with juvenile onset, which was recalcitrant to traditional topical and systemic therapy. He was successfully treated with anti-TNF-α monoclonal antibody, infliximab. The patient showed resolution with minimal disease activity, and was maintained on acitretin and emollients. The response to infliximab in our patient and in the previously reported cases confirms a role of anti-TNF-α therapy as an effective option in the treatment of PRP.
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KEYWORD
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Anti-TNF-α monoclonal antibody, Infliximab, Pityriasis rubra pilaris
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